Paper ID: 25
1 CABIMER/University of Seville-CSIC (Spain)
2 CABIMER / CSIC (Spain)
Many cells, from yeast to higher eukaryotes, divide asymmetrically. During an asymmetric cell division, different polarized factors can segregate preferentially to only one of the two resulting cells, which acts as a mechanism for the generation of cellular diversity. An ideal model to study asymmetric division is the budding yeast Saccharomyces cerevisiae. Interestingly, in this organism the spindle pole bodies (SPBs, the equivalent of the centrosomes in budding yeast) are asymmetrically distributed during cell division, so that they display a non-random inheritance between the mother and bud. Specifically, the old SPB, which is inherited from the previous mitosis, is segregated to the daughter cell, while the new SPB, which is assembled de novo, is retained in the mother cell. Remarkably, asymmetric inheritance of the centrosomes has been also shown in higher eukaryotes, where the age of the centrosome can specify the fate of the cell and the disruption of this inheritance pattern can determine important consequences. We have identified a new factor that is necessary for the establishment of this non-random inheritance pattern of the SPBs between the mother and the daughter cell in budding yeast.