YEAST 2017

28th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)

August 27 – September 1, 2017
Prague, Czech Republic

Paper ID: 25

A New Factor Involved in the Establishment of the Non-random Inheritance Pattern of the Spindle Pole Bodies in Saccharomyces Cerevisiae

Matellán Laura1, Manzano-López Javier1, Monje-Casas Fernando2

1 CABIMER/University of Seville-CSIC (Spain)
2 CABIMER / CSIC (Spain)


Many cells, from yeast to higher eukaryotes, divide asymmetrically. During an asymmetric cell division, different polarized factors can segregate preferentially to only one of the two resulting cells, which acts as a mechanism for the generation of cellular diversity. An ideal model to study asymmetric division is the budding yeast Saccharomyces cerevisiae. Interestingly, in this organism the spindle pole bodies (SPBs, the equivalent of the centrosomes in budding yeast) are asymmetrically distributed during cell division, so that they display a non-random inheritance between the mother and bud. Specifically, the old SPB, which is inherited from the previous mitosis, is segregated to the daughter cell, while the new SPB, which is assembled de novo, is retained in the mother cell. Remarkably, asymmetric inheritance of the centrosomes has been also shown in higher eukaryotes, where the age of the centrosome can specify the fate of the cell and the disruption of this inheritance pattern can determine important consequences. We have identified a new factor that is necessary for the establishment of this non-random inheritance pattern of the SPBs between the mother and the daughter cell in budding yeast.

Mitosis, Asymmetric cell division, Spindle pole bodies
Presented as:
  Poster [PS5-1] in PS5 Cell polarity, morphogenesis and cytoskeleton dynamics
  Oral presentation [S6-4] in S6 Cell cycle and cell fate

Institute of Microbiology

YEAST 2017
28th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)

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