YEAST 2017

28th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)

August 27 – September 1, 2017
Prague, Czech Republic


Paper ID: 253

Systems Metabolic engineering of Yeast

Nielsen Jens

Chalmers University of Technology (Sweden)

ABSTRACT

Metabolism represents the core of cellular functions and all cellular processes interact with metabolism through the use of specific metabolites, free energy and/or electron flows. However, metabolism is highly complex involving a large number of chemical reactions, and it is therefore difficult to study metabolism. The many different reactions are traditionally grouped into pathways with dedicated functions, but recent analysis of metabolism has shown that there is a high degree of connectivity between these pathways due to common sharing of co-factors and key metabolites. Also regulation of metabolism is complex due to the requirements for maintaining cellular homeostasis. In this talk I will give illustrations of how different parts of cellular metabolism are connected, i.e. central carbon metabolism, lipid metabolism and protein secretion. I will illustrate how metabolism can be modelled at the genome-scale and how incorporation of protein crowding may be a key determinant for cellular function, and keep proteome homeostasis is an important driver for maintaining proper cellular function. Finally, I will discuss how regulation of metabolism can be studied using different omics analysis, e.g. how we can get new insight into transcriptional regulation through ChIP-exo analysis.

Keywords:
metabolic engineering, systems biology, metabolism
Presented as:
  Oral presentation [S7-1] in S7 New biotechnologies

Institute of Microbiology

YEAST 2017
28th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)

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