YEAST 2017

28th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)

August 27 – September 1, 2017
Prague, Czech Republic

Paper ID: 325

ER-PM Contacts: Principals of PI Kinase Signaling and Membrane Organization

Nishimura Taki1, Chung Gary1, Stefan Christopher2

1 University College London (United Kingdom)
2 MRC Laboratory for Molecular Cell Biology, University College London (United Kingdom)


The plasma membrane (PM) is highly dynamic and undergoes extensive remodelling during regulated exocytosis and endocytosis. The PM is also spatially organised into distinct domains, including cortical endoplasmic reticulum (ER)-associated PM zones and ER-free PM zones. ER-PM contacts are recognised as important sites for non-vesicular calcium and membrane lipid transport, while exocytic and endocytic vesicular trafficking events are thought to take place exclusively in ER-free PM zones. These two PM domains have been considered to be functionally and spatially uncoupled. Our work is revealing vital roles for inter-organelle cross talk between the ER and PM in membrane trafficking pathways. We are addressing how the architecture of ER-PM contacts is regulated and how distinct ER-PM contacts govern PM domain organization and dynamics. We will present our recent findings on roles for membrane lipid dynamics taking place at ER-PM contacts in the control of phosphoinositide (PI) kinase regulatory networks during regulated exo- and endocytosis.

membrane organization, organelle dynamics, PI kinase signaling
Presented as:
  Oral presentation [S4-2] in S4 Organelle dynamics

Institute of Microbiology

YEAST 2017
28th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)

Copyright © Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic, 2016-2017  |  Privacy policy

Developed by SEOman. Powered by open source: LAMP, jQuery and Bootstrap.